Degenerative and inflammatory changes increase the catabolism of proteoglycans and glycoproteins.
An abnormal functioning immune system, incapable of recognizing its own tissue, manufactures antibodies against the cartilage and bone tissues.
Deposition of uric acid crystals on the articular surface of the joints.
All three of these types of arthritis lead to:
• Gradual loss of protioglycans that holds fluids inside the cartilage tissue.
• Gradual loss of glycoproteins that holds the cells together
And . . .